Laryngeal amyloidosis is a rare condition in which an abnormal protein — amyloid — deposits in the tissues of the larynx, most often in the supraglottis or laryngeal ventricles. The deposits appear as pale, waxy, submucosal masses. Because the deposition is gradual and painless, patients often present late, with hoarseness that has been worsening for months or years.
Treatment
Treatment is surgical debulking — typically using a CO₂ laser through the endoscope to remove as much amyloid as possible while preserving the delicate vocal fold mucosa. Recurrence is common; amyloid deposits tend to return and patients often require periodic repeat procedures.
This page will be expanded with endoscopic photographs and additional clinical detail.